Antigen Triggering Selectively IncreasesTCRBVGene Transcription
نویسندگان
چکیده
منابع مشابه
Antigen triggering selectively increases TCRBV gene transcription.
When the TCR binds Ag it is phosphorylated, internalized, and degraded. We wished to examine whether this process was accompanied by a specific concomitant increase in TCR mRNA levels. To do this, PBMC and a T cell clone were cultured with a series of superantigens and an alloantigen. Only T cells specifically responding to an antigenic stimulus had increased levels of TCR beta-chain variable (...
متن کاملThe dissociation activation model of B cell antigen receptor triggering.
To detect its cognate antigen, each B lymphocyte contains up to 120000 B cell antigen receptor (BCR) complexes on its cell surface. How these abundant receptors remain silent on resting B cells and how they can be activated by a molecularly diverse set of ligands is poorly understood. The antigen-specific activation of the BCR is currently explained by the cross-linking model (CLM). This model ...
متن کاملp26: a cell surface antigen expressed selectively by hematopoietic cells.
A monoclonal antibody (MoAb) H5 (IgG2b) was obtained by fusion between SP2/0, mouse myeloma cell line and spleen cells from BC3Fl mice immunized with HEL, a erythroleukemia cell line. MoAb H5 precipitated a 26 kilodalton (KD) polypeptide in reduced condition. It reacted with platelets, monocytes, eosinophiles, 13% of lymphocytes, thymocytes and colony-forming unitsgranulocyte/monocyte (CFU-GM),...
متن کاملActivation and Desensitization of Ionotropic Glutamate Receptors by Selectively Triggering Pre-existing Motions
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are key players in synaptic transmission and plasticity. They are composed of four subunits, each containing four functional domains, the quaternary packing and collective structural dynamics of which are important determinants of their molecular mechanism of function. With the explosion of structural studies on differen...
متن کاملSmall molecule selectively suppresses MYC transcription in cancer cells.
Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription. Given the critical role the oncogene MYC plays in tumor initiation and maintenance, we explored the potential of stauprimide as an anticancer agent. Here we report tha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2000
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.165.4.2020